Though it was long widely assumed that dopaminergic modulation is solely responsible for the respective antidepressant and antipsychotic properties of amisulpride, it was subsequently found that the drug also acts as a potent antagonist of the serotonin 5-HT 7 receptor (K i = nM).  Several of the other atypical antipsychotics such as risperidone and ziprasidone are potent antagonists at the 5-HT 7 receptor as well, and selective antagonists of the receptor show antidepressant properties themselves. To characterize the role of the 5-HT 7 receptor in the antidepressant effects of amisulpride, a study prepared 5-HT 7 receptor knockout mice.  The study found that in two widely used rodent models of depression, the tail suspension test, and the forced swim test, those mice did not exhibit an antidepressant response upon treatment with amisulpride.  These results suggest that 5-HT 7 receptor antagonism mediates the antidepressant effects of amisulpride.