To produce the mature form, a series of enzymes are required. First, a protease cleaves to the C-terminal side of the flanking Lys-Arg or Arg-Arg. Second, a carboxypeptidase removes the Lys/Arg residues leaving Gly as the C-terminal residue. Then, this Gly is converted into an amide residue by a series of enzymes collectively known as peptidylglycine-alpha-amidating monooxygenase. Concurrently with these processing steps, the N-terminal Gln ( glutamine ) is converted into pyroglutamate (a cyclic residue). These multiple steps produce 6 copies of the mature TRH molecule per precursor molecule for human TRH (5 for mouse TRH).
Hormone therapy can help relieve the symptoms of perimenopause and menopause. Hormone therapy means taking estrogen and, if you have never had a hysterectomy and still have a uterus, progestin . Progestin is a form of progesterone. Taking progestin helps reduce the risk of cancer of the uterus that occurs when estrogen is used alone. If you do not have a uterus, estrogen is given without progestin. Estrogen plus progestin sometimes is called “combined hormone therapy” or simply “hormone therapy.” Estrogen-only therapy sometimes is called “estrogen therapy.”
Before birth a baby is entirely dependent on the mother for thyroid hormone until the baby's own thyroid gland can start to function. This usually does not occur until about 12 weeks of gestation (the end of the first trimester of pregnancy). Thus, hypothyroidism of the mother may play a role early on, before many women realize they are pregnant! In fact, the babies of mothers who were hypothyroid in the first part of pregnancy, then adequately treated, exhibited slower motor development than the babies of normal mothers. However, during the later part of pregnancy, hypothyroidism in the mother can also have adverse effects on the baby, as pointed out by the research described above. These children are more likely to have intellectual impairment.