Fish oil fatty acids interact with the peroxisome proliferator-activated receptor (PPAR) system, which are a class of receptors (PPARα, PPARβ/δ, and PPARγ) that seem to respond to dietary lipids and similarly structured molecules. They are highly involved in the treatment of diabetes and metabolic syndrome (via the drug classes of fibrates and thiazolidinediones), with varying effects on fat mass (PPARα increases beta-oxidation of fatty acids,  while PPARγ promotes fat storage but improves insulin tolerance;  PPARδ appears to be similar to PPARα in this regard  ).
I’ve been fighting shingles now for 6 weeks and I’m still suffering from pain where the shingles blisters were located. I started 15 billion probiotics midway thru this and was feeling better. I was taking 5 billion 3 times a day. A friend coaxed me to bump it up to 20 billion. So I did this and by the 3rd day I had a rash all over my head. I’ve since stopped and the rash has gone away. I really want to go back on it, but now I’m stuck with 20 billion capsules. Any ideas on breaking these capsules in half to take half in the morning then again at night? Or should I wait til after this shingle pain goes away? I’m sure I’m in toxic overload with having fibromyalgia and type 2 diabetes. What would u suggest I do? Thank you.
Benzodiazepine therapy can give rise to physiologic and psychologic dependence based on the drug's dosage, duration of therapy and potency. 1 Thus, dependence will develop sooner (such as in one to two months) in a patient who is taking a high dosage of a high-potency agent such as alprazolam than in a patient who is receiving a relatively low dosage of a long-acting, low-potency agent such as chlordiazepoxide. As a result of physiologic dependence, withdrawal symptoms emerge with rapid dose reduction or abrupt discontinuation of the drug.