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A number of investigators have reported on a rather rare syndrome of excess aromatase activity. In boys, it can lead to gynecomastia , and in girls to precocious puberty and gigantomastia . In both sexes, early epiphyseal closure leads to short stature. This condition is due to mutations in the CYP19A1 gene which encodes aromatase.  It is inherited in an autosomal dominant fashion.  It has been suggested that the pharaoh Akhenaten and other members of his family may have suffered from this disorder,  but more recent genetic tests suggest otherwise.  It is one of the causes of familial precocious puberty—a condition first described in 1937.