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Some, semi-common conditions that affect a good portion of society, and more who are non optimal excercisers: methylation problems (active folate, B12, b6 issues pyrroles (zinc, active b6, gla and some magnesium) (see Walsh protocols for a wide range of conditions from variouse malfunction, including sulphication issues, includes methylation) these are issues common in autism spectrum disorders, with Asperger’s being part of the disorder, I suspect trials on University students that be skewed by this), nor-adrenalin, copper vitamin C, iron or zinc and other issues, and people with ATP dysfunction, such as from the virus associated with chronic fatigue. Either a supplement addresses issues, or the underlying physiology might have to run smoothly to maximise it’s affect.