The choice to keep POJOs pure doesn't come without cost. Rather than spending the effort to develop and maintain complex configuration files it is possible to simply use annotations to mark classes and let spring do the rest of the work. Resolving dependencies can be simple if they follow a convention such as matching by type or by name. This is choosing convention over configuration .  It is also arguable that, when refactoring to another framework, removing framework specific annotations would be a trivial part of the task  and many injection annotations are now standardized.  
Humira is a biologic medicine that is injected subcutaneously into the thigh or abdomen. This set of instructions will focus on the injection into the thigh. It is used to treat patients with Arthritis, Ulcerative Colitis, Ankylosing Spondylitis, and Crohn’s Disease. If you are new to this medicine or the method of self-injection, you might feel hesitant to administer yourself the medicine due to being unclear on how to perform the process. Below are steps on what you’ll need, where to set yourself up for the injection, how to prep yourself, and how to actually perform the injection itself. These steps will provide you with the confidence and clarity to use the self-injecting Humira Pen.